The early slate is posted. Here’s the 4:05 and 4:25 window, plus Sunday Night Football and Monday Night Football, to close out Week 6.
Odds via bet365. Lines move fast on game day so double check the app before you actually fire anything in.
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Late Window (4:05 / 4:25 PM ET)
Cardinals at Rams: Rams -12.5 (LAR -650 / ARI +475), O/U 52.5 Our Pick: Rams 35, Cardinals 20 (Rams -12.5) Sean McVay is 33-23 against the spread after a loss, and the Rams are coming off an overtime loss to Buffalo on Monday night. Arizona is 1-4 after getting blown out 45-21 by Detroit, and Los Angeles has won 16 of the last 20 meetings. That’s a big number, but this game is indoors at SoFi and we trust the Rams offense to put up points and the Cardinals defense to give them up. Give us the Rams to cover.
Chargers at Chiefs: Chiefs -8.5 (KC -390 / LAC +310), O/U 43.5 Our Pick: Chiefs 27, Chargers 13 (Under 43.5) The Chiefs are 4-0 and coming off the bye, Kenneth Walker III is second in the league in rushing with 537 yards, and Mahomes looks back to form. Los Angeles is 0-5 and has the lowest average depth of target in the league (4.2 yards), while Kansas City’s defense gives up one of the lowest air yards per attempt in the NFL. The Chiefs rank seventh in scoring defense at 19.3 points per game, and the under is 7-1 in their past eight home games as a favorite of seven or more points. A Kansas City team that wants to run the ball and keep the clock moving against a Chargers offense that can’t stretch the field is a recipe for a low-scoring game. We’ll take the under.
Bills at Raiders: Bills -5.5 (BUF -275 / LV +225), O/U 52.5 Our Pick: Bills 31, Raiders 24 (Over 52.5) Josh Allen is hard to bet against right now and the Raiders have lost two straight after their hot start, but Buffalo’s defense is the real story. The Bills rank 30th in yards allowed (388.6 per game) and 28th in scoring defense (28.2 points per game), and Brock Bowers is a tough matchup for a struggling secondary. Buffalo stayed out west after the Monday night overtime win over the Rams, and the over is 7-2 in the Bills’ past nine games as a favorite. Both offenses should score, so we’re taking the over.
Sunday Night Football
Cowboys at Packers: Packers -1.5 (DAL -106 / GB -114), O/U 52.5 Our Pick: Cowboys 31, Packers 28 (Cowboys moneyline) Since 2024 the Cowboys are 5-0 outright as road underdogs of three points or less, and this one is essentially a pick’em at Lambeau. Dallas is coming off a Thursday night loss to Tampa Bay, which gives them extra rest, and Dak Prescott has CeeDee Lamb and George Pickens to work against a banged-up Green Bay defense. The Packers convert just 27.6% of their third downs, and while Jordan Love lit up the Bears, we expect Dallas to keep pace. Give us the Cowboys on the moneyline.
Monday Night Football
Commanders at 49ers: 49ers -7.5 (WSH +330 / SF -420), O/U 50.5 Our Pick: 49ers 34, Commanders 24 (Over 50.5) The 49ers are 5-0, Brock Purdy is looking like an early MVP candidate, and nobody has been able to cover Mike Evans. San Francisco won a thriller in Seattle last week, 32-29, and this line has jumped from -5.5 to -7.5. Washington is 1-3-1 after the tie with the Giants and has been allowing plenty of points, and the over has hit in five straight 49ers games as a favorite of at least 3.5 points. We think the Niners win comfortably, but the Commanders score enough to push this over.
Our Best Bet of the Late Slate and Prime Time: Under 43.5 in Chargers-Chiefs. An 0-5 Chargers offense with the lowest depth of target in the league against a top-10 Chiefs defense, with the under 7-1 in Kansas City’s recent home games as a big favorite.
That’s the Week 6 card. Couch Side Sports out. Let us know your locks.
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